Rho-kinase: regulation, (dys)function, and inhibition
نویسندگان
چکیده
منابع مشابه
Improved erectile function after Rho-kinase inhibition in a rat castrate model of erectile dysfunction.
Androgens are reported to act as strong modulators of erectile function influencing both nitric oxide and vasoconstrictor signaling. Castration results in a depressed erectile response that is associated with a loss of nitric oxide production and increased responsiveness to constrictive agents. The increased vasoconstrictor response may be a result of an active RhoA/Rho-kinase signaling pathway...
متن کاملAcute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation
OBJECTIVES Activation of RhoA/Rho-kinase (ROCK) is increasingly implicated in acute vasospasm and chronic vasoconstriction in major organ systems. Therefore we aimed to ascertain whether an increase in ROCK activity plays a role in the deterioration of coronary vascular function in early stage diabetes. METHODS Synchrotron radiation microangiography was used to determine in vivo coronary resp...
متن کاملInterleukin-17 causes Rho-kinase-mediated endothelial dysfunction and hypertension.
AIMS Elevated levels of pro-inflammatory cytokine interleukin-17A (IL-17) are associated with hypertensive autoimmune diseases; however, the connection between IL-17 and hypertension is unknown. We hypothesized that IL-17 increases blood pressure by decreasing endothelial nitric oxide production. METHODS AND RESULTS Acute treatment of endothelial cells with IL-17 caused a significant increase...
متن کامل1 Inhibition of Rho kinase enhances adipogenesis through the regulation of G1/S transition
kinase II enhances adipogenesis Michio Noguchi, Kiminori Hosoda*, Junji Fujikura, Muneya Fujimoto, Hiroshi Iwakura, Tsutomu Tomita, Takako Ishii, Naoki Arai, Masakazu Hirata, Ken Ebihara, Hiroaki Masuzaki, Hiroshi Itoh, Shuh Narumiya, and Kazuwa Nakao From the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan and Department of Pharm...
متن کاملThe role of RhoA/Rho kinase pathway in endothelial dysfunction
Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a vari...
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ژورنال
عنوان ژورنال: Biological Chemistry
سال: 2013
ISSN: 1437-4315,1431-6730
DOI: 10.1515/hsz-2013-0181